Resolvins and Protectins in Inflammation-Resolution
Resolvins and Protectins in Inflammation-Resolution.pdf
Resolvins and Protectins in Inflammation-Resolution
1. Introduction
The critical role of inflammatory processes in health and disease
has long been recognized,1
yet the detailed molecular mechanisms and
biological events that regulate the progression and resolution of inflammation remain of interest.
A number of recent investigations have
provided strong evidence that the resolution of inflammation is not a passive process, as
believed earlier.2–4 Instead, resolution is a biosynthetically active process, regulated by
biochemical mediators and receptor-signaling pathways, and driven by specialized proresolving
mediators (SPM). In particular, following a number of findings by Serhan and his
group, the authors and their collaborators introduced and systematically investigated a
number of SPM derived from polyunsaturated fatty acids (PUFA), including lipoxins, Eseries
resolvins, D-series resolvins, protectins/neuroprotectins, and, most recently, maresins.
This review summarizes efforts on the resolvins and protectins with an emphasis on the
corresponding biochemical pathways. Additional reviews covering different aspects of these
anti-inflammatory and pro-resolving lipid mediators,5
including immunology,6,7 pathology,8
biochemistry,9
pharmacology10 and chemistry11 are also available.6–9,
Resolvins and protectins mediatin solutions to inflammation.pdf