Resolvins and Protectins in Inflammation-Resolution.pdf
Resolvins and Protectins in Inflammation-Resolution
1. Introduction
The critical role of inflammatory processes in health and disease
has long been recognized,1
yet the detailed molecular mechanisms and
biological events that regulate the progression and resolution of inflammation remain of interest.
A number of recent investigations have provided strong evidence
that the resolution of inflammation is not a passive process, as believed earlier.2–4
Instead, resolution is a biosynthetically active process,
regulated by biochemical mediators and receptor-signaling pathways,
and driven by specialized proresolving mediators (SPM).
In particular, following a number of findings by Serhan and his group, the authors and their collaborators introduced and systematically investigated a number of SPM derived from polyunsaturated fatty acids (PUFA), including lipoxins, Eseries resolvins, D-series resolvins, protectins/neuroprotectins, and, most recently, maresins. This review summarizes efforts on the resolvins and protectins with an emphasis on the corresponding biochemical pathways. Additional reviews covering different aspects of these anti-inflammatory and pro-resolving lipid mediators,5 including immunology,6,7 pathology,8 biochemistry,9 pharmacology10 and chemistry11 are also available.6–9,
Resolvins and protectins mediatin solutions to inflammation.pdf
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